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Sjögren's Syndrome Part 3: Treatment Approaches

If you've been following along, you're likely gaining a deeper understanding of this complex autoimmune condition that affects millions worldwide. Today, we will dive into treatment approaches, exploring various cases and shedding light on how rheumatologists approach managing symptoms associated with Sjögren's.

First, let's reiterate that every patient's journey with Sjögren's is unique.

What works for one individual may not necessarily work for another. Hence, the information provided here is not medical advice, but rather an insight into the thought process of rheumatologists when addressing symptoms like dry eyes, dry mouth, and autoimmune complications associated with Sjögren's.

Let's start by discussing a few patient cases to illustrate different treatment strategies.

Addressing Fatigue and Joint Pain

Imagine a patient in her 50s, a professor, experiencing debilitating fatigue alongside dry eyes and mouth, and mild joint pain. In this scenario, we initiated treatment with hydroxychloroquine (Plaquenil), a medication known to restore immune balance. While evidence supporting its efficacy in combating fatigue is limited, in some cases, like this one, it proved beneficial. Within a month, the patient reported significant improvement in fatigue, although joint pain relief took longer to manifest.

Managing Severe Joint Pain

In another case, a patient presented with severe joint pain, indicative of inflammatory arthritis, alongside dry eyes and mouth. Treatment involved a combination approach: addressing dryness symptoms and initiating hydroxychloroquine. Remarkably, the patient experienced relief from joint pain, highlighting the efficacy of this treatment regimen.

Dealing with Neuropathic Pain

Consider a patient with widespread pain, particularly sensitive to touch, resembling small fiber neuropathy or fibromyalgia. For such cases, the focus shifts to managing neuropathic pain symptoms. Treatment may involve medications like Cymbalta, which not only alleviates pain but also improves overall quality of life.

Treating Pulmonary Involvement

In instances where Sjögren's manifests with complications like lung involvement leading to shortness of breath, a more aggressive treatment approach is warranted. Immunomodulatory or immunosuppressive agents such as rituximab may be prescribed to address the underlying inflammation and prevent further damage.

General Treatment Considerations

In managing Sjögren's, rheumatologists adopt a two-pronged approach:

Immunomodulation/Immunosuppression: Tailored to the severity of symptoms and organ involvement. Mild cases may benefit from medications like hydroxychloroquine, while severe cases may require more potent agents like rituximab.

Symptom Management: Addressing dryness-related symptoms such as dry eyes and mouth involves a variety of interventions, including eye drops, punctal plugs to retain tears, and medications like cevimeline or pilocarpine for dry mouth.

Beyond medications, lifestyle modifications play a crucial role in managing Sjögren's symptoms:

  1. Exercise: Stimulates the immune system, boosts energy levels, and aids in overall well-being.

  2. Sleep Hygiene: Establishing a regular sleep schedule and minimizing screen time before bed can improve sleep quality.

  3. Dental and Eye Care: Regular dental check-ups and eye exams are essential to maintain oral and ocular health.

  4. Regular Monitoring: Routine visits to healthcare providers help track disease progression and adjust treatment plans accordingly.

In conclusion, while Sjögren's Syndrome presents unique challenges, advancements in research offer hope for improved management strategies. By understanding the nuances of this condition and adopting a comprehensive treatment approach, patients can strive for better symptom control and enhanced quality of life.

Remember, you're not alone in this journey. Your rheumatologist is your ally, working tirelessly to find the most effective solutions tailored to your individual needs. Stay informed, stay proactive, and together, we can navigate the complexities of Sjögren's Syndrome with optimism and resilience.


Are you or a loved one grappling with Sjogren Syndrome? UnabridgedMD in Rheumatology is your beacon of expertise when it comes to understanding autoimmune conditions like Sjogren Syndrome. Our personalized approach to patient care is designed to empower individuals, providing them with the necessary resources and support for a successful health journey. 

Dr. Isabelle Amigues of UnabridgedMD has been voted best rheumatologist in Denver, Colorado! We can't wait to welcome you to the family.

You can schedule your first appointment at or schedule a free 15 minute discovery call with Dr. Amigues herself by clicking  HERE.


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